Interview
I would like to thank NanA onlus for the opportunity that gave me to start my PhD in Immunology, Molecular Medicine and Applied Biotechnology at the University of Tor Vergata. I sincerely also thank this Onlus and Professor Maria Teresa Voso for welcoming me into their team and for guiding and motivating me every day during my studies and research.
Last year, we conducted a nationwide survey (the first in Italy), enrolling patients suffering from Vexas Syndrome, from different hospitals that joined the study. The goal was to collect important clinical and therapeutic information about the disease.
I was involved in laboratory activities of Advanced Hematology Diagnostics: processing of peripheral and bone marrow blood samples from patients at diagnosis and at various timepoints of Vexas syndrome, DNA extraction, sequencing by Sanger method, ddPCR analysis, study of clonal dynamics of UBA1 gene.
My main research fields are: myelodysplastic syndromes, Vexas syndrome (which is still being clinically and therapeutically defined), and acute myeloid leukemias with special attention to core-binding-factor leukemias with chromosome 16 inversion. I have mainly done clinical activity and research in the Vexas Syndrome setting.
I started my PhD in Immunology, Molecular Biology and Applied Biotechnology at the Department of Biomedicine and Prevention in November 2023.
I am now attending the second year of my PhD. For work reasons, I moved to Campobasso in April 2023, so I am continuing to do mainly data collection activities.
Biosketch
Maria Rosaria Pascale MD, PhD
Laurea in Medicina e Chirurgia
23 Marzo 2018
Settembre 2011àMarzo 2018
Università degli Studi del Molise
110/110 con lode
“L’impatto della targeted therapy e dell’immunoterapia sugli outcomes clinici dei pazienti affetti da carcinoma renale metastatico”
Diploma di Specializzazione in Ematologia
15 Novembre 2022 Università degli Studi di Roma Tor Vergata 50/50 con lode
“Composizione corporea nei pazienti affetti da linfoma follicolare: cambiamenti dei parametri radiomici nei pazienti trattati con regimi R-CHOP e R-Bendamustina”
Among the major publications:
1. Paterno G, Palmieri R, Forte V, Del Prete V, Gurnari C, Guarnera L, Mallegni F, Pascale MR, Buzzatti E, Mezzanotte V, Cerroni I, Savi A, Buccisano F, Maurillo L, Venditti A, Del Principe MI. Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience. Cancers (Basel). 2022 Nov 17;14(22):5640. doi: 10.3390/cancers14225640. PMID: 36428732.
2. Gianmario Pasqualone, Elisa Buzzatti, Raffaele Palmieri, Arianna Savi, Maria Rosaria Pascale, Beatrice Borsellino, Luca Guarnera, Francesco Buccisano, Maria Teresa Voso, Luca Maurillo, Giuseppe Sconocchia, Adriano Venditti and Maria Ilaria Del Principe. Case report: A Saprochaete clavata(Magnusiomyces clavatus) severe infection effectively treated with granulocyte transfusion in a young patient with myeloid sarcoma. Oncol., Sec. Hematologic Malignancies. doi 10.3389/fonc.2022.970188 Published: Semptember 15, 2022.
