My team has recently published several studies demonstrating the role of 8-oxodG in transcription regulation, offering valuable insights into how DNA damage impacts gene expression. We are now investigating whether 8-oxodG might actively drive transcription rather than being just a byproduct of RNA Polymerase II activity. By understanding the molecular mechanisms by which 8-oxodG controls transcription and chromatin 3D structure, we envision targeting the 8-oxodG to reprogram altered cellular transcription programs. This approach could represent a novel therapeutic strategy for diseases such as cancer and neurodegenerative disorders.